Kidepo's mammal list of over 80 species includes 28 that are found in no other Ugandan National park. Amongst these are such charismatic African animals as Bat-eared Fox, Carcal, Cheetah and Klipspringer. Unfortunately, Kidepo suffered the same fate as many other Ugandan parks during the Amin era and is still recovering from years of poaching that left game herds depleted. Striped Hyena, Lesser Kudu, Grant's Gazelle and Beisa Oryx have not been seen at all in recent times and are presumed to be locally extinct.
Other large mammals have shown a remarkable recovery and there are now healthy population of Elephant, Common Zebra, Buffalo, Bohor Reedbuck, Waterbuck and Kongoni. Predators are plentiful and Spotted Hyena, Leopard and Lion are frequently seen. Oribis is abundant in the Narus Valley, whilst the dry thorn thickets in the north are home to Guenther's Dik Dik. Senegal Galago and Sidestriped Jackal may be found in the rest camp at night and White-tailed Mongoose is common but more likely to be found on a night drive. The park also has a very rich and diverse reptile fauna.